Selected Publications
1. Nahmad AD, Lazzarotto CR, Zelikson N, Kustin T, Tenuta M, Huang D, Reuveni I, Nataf D, Raviv Y, Horovitz-Fried M, Dotan I, Carmi Y, Rosin-Arbesfeld R, Nemazee D, Voss JE, Stern A, Tsai SQ, Barzel A. “In vivo engineered B cells retain memory and secrete high titers of anti-HIV antibodies in mice”.
Nature Biotechnology, 40(8), 1241–1249. https://doi.org/10.1038/s41587-022-01328-9
2. Nahmad A. D.^, Reuveni E.^, Goldschmidt E.^, Tenne T., Liberman M., Horovitz-Fried M, Khosravi R., Kobo H., Reinstein E., Madi A.*, Ben-David U.*, Barzel A. “Frequent Aneuploidy in Primary Human T Cells Following CRISPR-Cas9 cleavage”. Nature Biotechnology, 2022 Jun 30. https://doi.org/10.1038/s41587-022-01377-0
3. Barzel, A., Paulk, N.K., Shi, Y., Huang, Y., Chu, K., Zhang, F., Valdmanis, P.N., Spector, L.P., Porteus, M.H., Gaensler, K.M. and Kay, M.A.*, “Promoterless gene targeting without nucleases ameliorates haemophilia B in mice” Nature. 2015 Jan 15;517(7534):360-4. https://doi.org/10.1038/nature13864
4. Nahmad A.D., Raviv Y, Horovitz-Fried M., Sofer I, Akriv T, Nataf D, Dotan I, Carmi I, Burstein D, Wine Y, Benhar I, Barzel A. "Engineered B cells expressing an anti-HIV antibody enable memory retention, isotype switching and clonal expansion". Nature Communications. 2020 Nov 17;11(1):585. https://doi.org/10.1038/s41467-020-19649-1
5. Chandler R.J., Venturoni L., Liao J., Hubbard B.T., Schneller J.L., Hoffman V., Gordo S., Zang S., Ko C.W., Chau N., Chiang K., Kay M.A., Barzel A., Venditti C.P.*, "Promoterless, nuclease-free genome editing confers a growth advantage for corrected hepatocytes in mice with methylmalonic acidemia". Hepatology. 2021 Jun;73(6):2223-2237. https://doi.org/10.1002/hep.31570
6. Borel F, Tang Q, Gernoux G, Greer C, Wang Z, Barzel A, Kay M.A., Shultz L.D., Greiner D.L., Brehm M.A., Flotte T.R., Mueller c.*, "Survival advantage of both human hepatocellular xenografts and genome corrected hepatocytes for treatment of α-1 antitrypsin deficiency". Molecular Therapy. 2017 Nov 1;25(11):2477-2489. https://doi.org/10.1016/j.ymthe.2017.09.020
7. Porro F, Bortolussi G, Barzel A, De Caneva A, Laconcig A., Vodret S, Zentilin L , Kay M.A. , Muro A.F.*, "Promoterless gene targeting without nucleases rescues lethality of a Crigler-Najjar syndrome mouse model" EMBO Molecular Medicine. 2017 Oct;9(10):1346-1355. https://doi.org/10.15252/emmm.201707601
8. De Caneva A, Porro F, Bortolussi G, Sola R, Lisjak M, Barzel A, Giacca M, Kay M.A, Vlahovicek K, Zentilin L and Muro A.F.*, "Coupling AAV-mediated promoterless gene targeting to SaCas9 nuclease to efficiently correct liver metabolic diseases". JCI insight. 2019 Jun;5(15):e128863. https://doi.org/10.1172/jci.insight.128863
9. Aizik L., Dror Y., Taussig D., Barzel A., Carmi Y., Wine Y.* "Antibody repertoire analysis of tumor-infiltrating B cells reveals distinct signatures and distributions across tissues". Frontiers in Immunology. 2021 Jul 19;12:705381. https://doi.org/10.3389/fimmu.2021.705381
10. Pozzi S, Scomparin A, Ben-Shushan D, Yeini E, Ofek P, Nahmad A. D., Barzel A, Brem H, Hyde T. M., Satchi-Fainaro R. , Astrocytes-melanoma MCP-1/CCR2 inhibition: a strategy to activate the brain microenvironment against melanoma metastasis. JCI insight, 7(17), e154804. https://doi.org/10.1172/jci.insight.154804